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I was in public when that kicked in and it was terrifying. One Adeno B12 sublingual will actually make me literally unable to form a sentence. My need for caffeine to get through the day is totally gone, I have tons of energy now.ĭespite the diet I still can't tolerate much b12 or folinic acid or methyl folate - more than a tiny dose once a week makes me unfunctional. I also took Ornithine/Arginine, Acetyl and L-Carnitine, and Malic Acid as supports.
#Cfs coffee free
I had never known about or noticed I reacted to thiols or sulfate/sulfite in my life, but after reading about CBS I tried a totally thiol and sulfur free diet and within 48 hours was a new person (so fast the change!). All of those are said to relate to a CBS upregulation. I have very low homocysteine (crazy abnormally low according to my Dr), an intolerance to things like ALA, glutathione, NAC, I'll pass out from a methyl B12 shot (doctors were always mystified by that one), very elevated liver enzymes despite healthy living and no alcohol, abnormal amino acid tests, etc. It's like flipping a switch in my immune system.Ĭlick to expand.Great idea on the poll.Īll of my unresolved lab tests and strange reactions to things finally made sense when I read about CBS and the myriad mechanisms there (note I also have 3 BHMT ++ and each of those also act like a CBS + even if you don't have any CBS+.)
#Cfs coffee skin
I made the mistake once of thinking, hey I feel fine, I don't have celiac after all! Within months the thyroid disease and skin cancer all came back with a vengeance.
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I feel fine if I eat gluten on occasion (not good for me, I know). There's also no "try it after not eating it for a while and see how you react". It takes that long at a minimum to clear it from the system and let possible inflammation settle down - way longer than other food tests. There's so much grey area across the gluten spectrum the best thing sometimes is just going 30-60 days without any trace of gluten and seeing if you feel significantly better. Sometimes the intestine actually looks normal on tests for celiac because a biopsy is a tiny piece and you can have normal areas and bad areas. But celiac brings on comorbid conditions like thyroid disease, painful skin rashes, skin cancer, other autoimmune disorders, etc, so you often know you have celiac not by looking at the intestine per se but looking at a cluster of other diseases (including severe malnutrition despite eating well). A lot of things aside from gluten, like food poisoning, can cause intestinal damage too. I know I'm celiac and that it runs in my family (Scandinavian blood is more vulnerable to it). I also still have not seen anyone attempt to explain how synonymous alleles in exons could ever cause problems, such as for CBS A360A and CBS N212N.Ĭlick to expand.I don't know. If CBS is causing problems, it's very unlikely it's contributing to ME, and is certainly not looking to be more prevalent in ME. For their ethnically matched controls, 5 are +/+ and 17 are +/. If well over 50% of the world's population had this supposed vulnerability to exploit, it would be massive and it would be extremely noticeable.Īnd for the 31 ME patients from this forum who I have 23andMe data for, 2 are +/+ for C699T and 12 are +/. If there is something interfering with CBS in such a manner, it would have to be entirely external, and would have nothing to do with specific SNPs on the gene.Īlso, it's generally claimed by Yasko and her followers that CBS C699T +/- and A360A +/- and +/+ also cause problems, not just C699T +/+. That doesn't mean that something isn't causing CBS to dramatically malfunction, but it does exclude CBS C699T from playing that role. In the case of CBS, it has been shown to work properly, and even slightly better than normal, for people with C699T +/+. Click to expand.In the case of your organophosphate problem, the gene has never worked properly, but has merely gone unnoticed until something comes along and exploits that.